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. 2014 Oct 8;11:52. doi: 10.1186/s12989-014-0052-6

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© Silva et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Ag NWs increase total BALF cells and protein. Graphs show absolute numbers of total cells (left), and proteins (right) in BALF on Days 1-21 post IT of S-Ag NWs (A-B), or L-Ag NWs (C-D). Results are from ANOVA considering dose, time, and particle length at p < 0.05. “D” corresponds specifically to differences between groups (in the same panel, sacrificed on the same day) given 1.0 mg/kg Ag NWs versus any other dose; while, “d” indicates differences from the sham control and 0.01 mg/kg groups only. “T” indicates differences between animals (in the same panel, given the same treatment) sacrificed on Day 1 versus Days 7 and 21; while, “t” indicates difference from Day 21 only. “A” indicates a significant difference between groups (in different panels) given the same dose of different Ag NW types (e.g. S- versus L-Ag NWs), but sacrificed on the same day.