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. 2014 Oct 8;11:52. doi: 10.1186/s12989-014-0052-6

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© Silva et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Ag NW instillation produced epithelial sloughing in bronchiolar regions. Panels are Brightfield microscopy images of the most severe responses in H & E-stained tissue sections, from rats instilled with a single dose of 1.0 ml/kg sham control (A, B, C), L-Ag NWs (D-E), or S-Ag NWs (F). Images show tissues at Days 1, 7, and 21 days post exposure to sham control (A-C, respectively), Days 1 and 7 post exposure to L-Ag NWs (C & D, respectively), and Day 21 post exposure to S-Ag NWs (F). Solid arrows indicate sloughed epithelial cells. Scale bar is 50 μm.