Table 2.

Univariate and Multivariate Analyses with Respect to EFS and OS.

	EFS						OS
	Univariate			Multivariate			Univariate			Multivariate
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Age	1.015	1.005-1.024	.003	1.016	1.000-1.033	.055	1.019	1.008-1.029	< .001	1.029	1.013-1.044	.001
Karyotype risk	1.613	0.799-3.253	.182	1.250	0.515-3.036	.622	2.059	1.004-4.224	.049	1.735	0.712-4.227	.225
Platelet counts	0.976	0.941-1.012	.191	0.967	0.894-1.047	.413	0.969	0.930-1.009	.124	0.923	0.840-1.014	.093
Marrow blasts (%)	1.007	0.991-1.024	.392				1.015	0.997-1.033	.108	1.001	0.980-1.022	.956
FLT3 mutation	0.693	0.389-1.234	.213				0.665	0.369-1.201	.176	0.414	0.163-1.055	.065
RUNX1 mutation	1.549	0.867-2.768	.140	2.365	0.946-5.915	.066	1.508	0.835-2.724	.173	2.326	0.978-5.533	.056
IDH mutation	0.950	0.531-1.702	.864				0.963	0.540-1.716	.897
RAS mutation	1.767	0.816-3.824	.149	2.405	0.679-8.518	.174	1.893	0.877-4.087	.104	1.728	0.500-5.975	.388
MLL-PTD	0.492	0.177-1.366	.173	0.525	0.143-1.921	.300	0.553	0.199-1.536	.256
ASXL1 mutation	0.898	0.279-2.888	.857				0.835	0.260-2.681	.762
DNMT3A mutation	1.375	0.425-4.442	.595				1.002	0.399-2.518	.996
P53 mutation	2.106	0.747-5.936	.159	0.942	0.263-3.373	.927	1.762	0.693-4.481	.234
PTPN11 mutation	0.61	0.190-1.960	.407				0.707	0.221-2.265	.559
TET2 mutation	0.445	0.174-1.142	.092	1.183	0.297-4.716	.812	0.437	0.169-1.128	.087	1.308	0.314-5.441	.712
Class I mutation	0.797	0.481-1.320	.378				0.714	0.426-1.196	.200
Class II mutation	1.492	0.850-2.617	.163				1.447	0.819-2.557	.204
Class III mutation	1.063	0.639-1.769	.813				1.150	0.686-1.927	.595
Class IV mutation	1.985	0.884-4.456	.097				1.712	0.804-3.645	.163