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Immunohistochemical preparations of two R-18 tumors stained for VEGF-A (A), VEGF-C (B), and LYVE-1 (C) and of the peritumoral skin of the tumors stained for LYVE-1 (C and D). Peritumoral lymphatics stained positively for LYVE-1 (C and D), whereas intratumoral lymphatics could not be detected (C). The images to the left refer to a tumor with a low IFP of 7 mmHg and those to the right to a tumor with a high IFP of 31 mmHg.
