Table 3. Cognitive functioning measures from the Wisconsin Card Sorting Test (WCST) and the Trail Making Test (TMT) in controls and in patients with schizophrenia who have C/C, C/T, and T/T BDNF C270T genotypes (mean [sd]).
Genotype | WCST number of categories achieved | WCST perseverative errors | TMT-A (seconds) | TMT-B (seconds) |
Patients | ||||
C/C (n=158) | 1.4 (2.9) | 16.3 (7.7) | 46.6 (17.9) | 115.8 (47.8) |
C/T (n=62) | 1.4 (2.8) | 15.9 (7.7) | 46.3 (18.5) | 116.7 (48.8) |
T/T (n=4) | 1.4 (2.9) | 16.4 (7.7) | 46.6 (18.0) | 117.1 (49.2) |
Controls (n=220) | 2.2 (2.4) | 10.2 (5.3) | 32.6 (12.2) | 56.6 (33.8) |
F | 10.36a | 13.68a | 26.62a | 16.56a |
p | 0.038 | 0.026 | 0.006 | 0.002 |
a Post-hoc SNK tests for all variables found that the three patient groups were all significantly different from controls but there were no significant differences between the three patient groups.