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. Author manuscript; available in PMC: 2015 Jul 10.
Published in final edited form as: Nat Commun. 2014 Jul 10;5:4355. doi: 10.1038/ncomms5355

Figure 2. The deep binding pocket of SANT1.

Figure 2

(a) Localization of different ligands in the binding pocket: SANT1 (orange), Anta XV (green), SAG1.5 (light blue), LY2940680 (magenta), and cyclopamine (cyan). (b) and (c) The shapes of the deep binding pockets in the structures of SMO_Anta XV (green) and SMO_SANT1 (yellow), respectively. (d) Superposition of the deep binding pockets in the structures of SMO_Anta XV and SMO_SANT1. The side chain movements induced by SANT1 binding are shown by arrows. (e) ΔpKi values (pKi wild type – pKi mutants) of the designed mutants for different SMO ligands in 3H-cyclopamine competition experiments. Shown in the graph are mean ± SEM of 3–4 independent experiments, see also Supplementary Table 1.

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