Table 2.
Patient characteristics and distributions of IDH mutations for all patients and within groups
|
CHARACTERISTIC |
All |
IDH1 codon 132: |
IDH1 codon 105 (synonymous SNP): |
IDH2 codon 140: |
IDH2 codon 172: |
||||
|---|---|---|---|---|---|---|---|---|---|
| Total n = 189 | Wild type | Mutation | Wild type | Variant | Wild type | Mutation | Wild type | Mutation | |
| Age median (range), years |
64 (19–88) |
63 (19–85) |
70 (30–88)* |
64 (19–88) |
66 (29–84) |
63 (19–88) |
66 (37–83)* |
64 (19–88) |
72 (46–74)* |
| Gender |
|
|
|
|
|
|
|
|
|
| Male |
95 |
90 |
5 |
85 |
10 |
85 |
10 |
92 |
3 |
| Female |
94 |
84 |
10 |
84 |
10 |
83 |
11 |
92 |
2 |
| Karyotype |
|
|
|
|
|
|
|
|
|
| Normal |
108 |
99 |
9 |
95 |
13 |
96 |
12 |
106 |
2 |
| Aberrant |
75 |
69 |
6 |
68 |
7 |
66 |
9 |
72 |
3 |
| Missing data |
6 |
6 |
|
6 |
|
6 |
|
6 |
|
| Risk group |
|
|
|
|
|
|
|
|
|
| Low |
32 |
31 |
1 |
30 |
2 |
29 |
3 |
31 |
1 |
| Intermediate |
87 |
80 |
7 |
72 |
15 |
75 |
12 |
86 |
1 |
| High |
55 |
51 |
4 |
52 |
3 |
51 |
4 |
52 |
3 |
| Missing data |
15 |
12 |
3 |
15 |
|
13 |
2 |
14 |
1 |
| FLT3 status |
|
|
|
|
|
|
|
|
|
| FLT3 wild type |
116 |
109 |
7 |
104 |
12 |
101 |
15 |
114 |
2 |
| FLT3-ITD |
37 |
34 |
3 |
32 |
5 |
33 |
4 |
36 |
1 |
| Missing data** |
36 |
31 |
5 |
33 |
3 |
34 |
2 |
34 |
2 |
| NPM1 status |
|
|
|
|
|
|
|
|
|
| NPM1 wild type |
99 |
92 |
7 |
87 |
12 |
88 |
11 |
96 |
3 |
| NPM1 mutation |
52 |
49 |
3 |
47 |
5 |
44 |
8 |
52 |
0 |
| Missing data** |
38 |
33 |
5 |
35 |
3 |
36 |
2 |
36 |
2 |
| Induction treatment response |
|
|
|
|
|
|
|
|
|
| Complete remission |
132 |
122 |
10 |
119 |
13 |
119 |
13 |
127 |
5 |
| Not complete remission |
49 |
44 |
5 |
43 |
6 |
43 |
6 |
49 |
0 |
| Missing information |
8 |
8 |
0 |
7 |
1 |
6 |
2 |
8 |
0 |
|
IDH1 codon 132 |
|
|
|
|
|
|
|
|
|
| Wild type |
174 |
|
|
157 |
17 |
153 |
21 |
169 |
5 |
| Mutation |
15 |
|
|
12 |
3 |
15 |
0 |
15 |
0 |
|
IDH1 codon 105 (synonymous SNP) |
|
|
|
|
|
|
|
|
|
| Wild type |
169 |
|
|
|
|
151 |
18 |
165 |
5 |
| Variant |
20 |
|
|
|
|
17 |
3 |
19 |
1 |
|
IDH2 codon 140 |
|
|
|
|
|
|
|
|
|
| Wild type |
168 |
|
|
|
|
|
|
163 |
5 |
| Mutation |
21 |
|
|
|
|
|
|
21 |
0 |
|
IDH2 codon 172 |
|
|
|
|
|
|
|
|
|
| Wild type |
184 |
|
|
|
|
|
|
|
|
| Mutation | 5 | ||||||||
*Mann–Whitney test for difference in age distribution between patients with IDH mutation (IDH1 or IDH2) and IDH wildtype patients, median 62 vs 69 years; p = 0.036.
**FLT3-ITD and NPM1 mutations were not routinely analyzed in all non-normal karyotype patients.