Table 3.
Cox regression of overall survival, forced entry method
| Covariates | N | HR | 95% CI | p |
|---|---|---|---|---|
| Age |
|
1.022 |
1.002-1.042 |
0.033 |
| Risk group |
|
|
|
|
| Low risk |
32 |
1 |
|
|
| Intermediate risk |
87 |
2.980 |
1.495-5.942 |
0.002 |
| High risk |
55 |
5.993 |
2.912-12.333 |
<0.001 |
| Treatment |
|
|
|
|
| Chemotherapy |
118 |
1 |
|
|
| Chemotherapy + allo-SCT |
56 |
0.231 |
0.118-0.450 |
<0.001 |
|
IDH1 codon 132 |
|
|
|
|
| Wild type |
162 |
1 |
|
|
| Mutated |
12 |
0.816 |
0.390-1.708 |
0.59 |
|
IDH2 codon 140 |
|
|
|
|
| Wild type |
155 |
1 |
|
|
| Mutated |
19 |
1.942 |
1.068-3.530 |
0.030 |
|
IDH2 codon 172 |
|
|
|
|
| Wild type |
169 |
1 |
|
|
| Mutated |
5 |
0.222 |
0.067-0.738 |
0.014 |
|
IDH1 SNP codon 105 GGC > GGT |
|
|
|
|
| Wild type |
154 |
1 |
|
|
| Variant | 20 | 1.496 | 0.812-2.756 | 0.196 |
95% CI = 95% Confidence interval; HR = Hazard ratio.
Significant P-values (P <0.05) in boldface.