Table 2.
Summary of effects on the endpoints progesterone synthesis and CYP1A1 mRNA expression. Substances affecting a similar molecular endpoint revealed additive effects for this specific endpoint. DMI: (ergosterol)demethylase inhibitor; ↓ significantly (p < 0.05) down-regulated; ↑ significantly (p < 0.05) up-regulated; = no changes observed.
| Substance Class | Progesterone Synthesis | Endpoint Specific Additive Effect? | CYP1A1 Expression | Endpoint Specific Additive Effect? | |
|---|---|---|---|---|---|
| Cyproconazole | Triazole (DMI-fungicide) | ↓ | Yes | = | No |
| Epoxiconazole | Triazole (DMI-fungicide) | ↓ | Yes | (↑) | Yes |
| Flusilazole | Triazole (DMI-fungicide) | ↓ | Yes | ↑ | Yes |
| Tebuconazole | Triazole (DMI-fungicide) | ↓ | Yes | ↑ | Yes |
| Prochloraz | Imidazole (DMI-fungicide) | ↓ | Yes | ↑ | Yes |
| Chlorpyrifos | Organophosphate- insecticide | = | No | ↑ | Yes |
| Triflusulfuron-methyl | Triazinylsulfonyl-urea-herbicide | = | No | = | No |