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. 2004 May 13;23(11):2314–2324. doi: 10.1038/sj.emboj.7600223

Figure 7.

Figure 7

Correlation between the equal versus unequal distribution of the apical membrane and proliferative versus neurogenic divisions of NE cells in heterozygous embryos of TIS21-GFP knock-in mice. The distribution of the apical membrane and the expression of TIS21-GFP in mitotic NE cells were analyzed as exemplified in Figure 4. For both, mitotic NE cells showing an equal distribution of the apical membrane (left columns, n=76) and an unequal distribution (right columns, n=39), the percentage of TIS21-GFP-negative (gray columns) versus TIS21-GFP-positive (green columns) cells was calculated. Data for various developmental stages (E9.5–14.5) and brain regions (forebrain, midbrain, hindbrain) were pooled because the principal observation that the majority of mitotic NE cells showing an equal distribution of the apical membrane are TIS21-GFP-negative, that is, proliferating, and the majority of the cells showing an unequal distribution are TIS21-GFP-positive, that is, neurogenic, was made irrespective of the developmental stage and brain region analyzed (for details, see Figure 6).