Table 2. Genes Significantly Dysregulated (p<0.01) in Peripheral Blood Mononuclear Cells from the Full Sample of PTSD Cases at Post-Deployment and Used in Predictive SVM Classifiers*.
| Transcript Cluster ID | Gene Symbol | Gene Product | Diagnostic Group Main Effect | ||
|---|---|---|---|---|---|
|
| |||||
| Fold-Change in Cases | F | p | |||
| 7971296 | EPSTI1 | Epithelial stromal interaction 1 (breast) | 1.66 | 7.6 | 8.6E-03 |
| 7921434 | AIM2 | Absent in melanoma 2 | 1.47 | 10.4 | 2.4E-03 |
| 8056408 | GALNT3 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) | 1.32 | 17.7 | 1.3E-04 |
| 7970096 | ING1 | Inhibitor of growth family, member 1 | 1.28 | 12.3 | 1.0E-03 |
| 8046861 | ITGAV | Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 1.23 | 10.3 | 2.5E-03 |
| 8102817 | ELF2 | E74-like factor 2 (ets domain transcription factor) | 1.23 | 8.7 | 5.2E-03 |
| 8124022 | DTNBP1 | Dystrobrevin binding protein 1 | 1.23 | 13.3 | 7.0E-04 |
| 8145175 | PDLIM2 | PDZ and LIM domain 2 (mystique) | 1.21 | 9.3 | 3.9E-03 |
| 7953032 | LRTM2 | Leucine-rich repeats and transmembrane domains 2 | 1.20 | 8.3 | 6.1E-03 |
| 7905131 | CA14 | Carbonic anhydrase XIV | 1.20 | 11.4 | 1.5E-03 |
| 8044613 | CBWD1 | COBW domain containing 1 | 1.20 | 10.7 | 2.1E-03 |
| 8067680 | PRIC285 | Peroxisomal proliferator-activated receptor A interacting complex 285 | 1.18 | 7.9 | 7.5E-03 |
| 8161537 | CBWD3 | COBW domain containing 3 | 1.18 | 8.3 | 6.2E-03 |
| 8155636 | CBWD3 | COBW domain containing 3 | 1.16 | 8.4 | 5.7E-03 |
| 8077099 | SCO2 | SCO cytochrome oxidase deficient homolog 2 (yeast) | 1.15 | 7.5 | 9.0E-03 |
| 8012953 | TRIM16 | Tripartite motif-containing 16 | 1.15 | 8.2 | 6.5E-03 |
| 8037355 | ZNF428 | Zinc finger protein 428 | 1.15 | 8.4 | 5.8E-03 |
| 8161587 | CBWD3 | COBW domain containing 3 | 1.15 | 7.4 | 9.3E-03 |
| 7963157 | RACGAP1 | Rac GTPase activating protein 1 | 1.15 | 9.2 | 4.0E-03 |
| 7982868 | CHAC1 | ChaC, cation transport regulator homolog 1 (E. coli) | 1.15 | 7.3 | 9.6E-03 |
| 7969638 | ENST00000459449 | Ncrna:snoRNA chromosome:GRCh37:13:95862598:95862702:1 | 1.14 | 9.1 | 4.3E-03 |
| 8053248 | C2orf65 | Chromosome 2 open reading frame 65 | 1.14 | 9.9 | 3.0E-03 |
| 8067773 | ZNF512B | Zinc finger protein 512B | 1.13 | 10.4 | 2.4E-03 |
| 8074916 | C22orf43 | Chromosome 22 open reading frame 43 | 1.12 | 10.7 | 2.1E-03 |
| 8139921 | CALN1 | Calneuron 1 | 1.11 | 11.1 | 1.7E-03 |
| 7921492 | IGSF9 | Immunoglobulin superfamily, member 9 | 1.10 | 7.3 | 9.6E-03 |
| 7975562 | PAPLN | Papilin, proteoglycan-like sulfated glycoprotein | 1.10 | 7.8 | 7.9E-03 |
| 7996219 | NDRG4 | NDRG family member 4 | 1.09 | 8.7 | 5.0E-03 |
| 7919267 | AK125616 | cDNA FLJ43628 fis, clone SPLEN2027268. | 1.09 | 8.4 | 5.8E-03 |
| 7919347 | AK125616 | cDNA FLJ43628 fis, clone SPLEN2027268 | 1.09 | 8.4 | 5.8E-03 |
| 8064242 | NCRNA00176 | Non-protein coding RNA 176 | 1.06 | 12.1 | 1.1E-03 |
|
| |||||
| 8161133 | SPAG8 | Sperm associated antigen 8 | -1.07 | 11.1 | 1.7E-03 |
| 7960434 | GENSCAN00000019809 | cDNA:Genscan chromosome:GRCh37:12:5141715:5142095:-1 | -1.07 | 8.6 | 5.4E-03 |
| 7901967 | ENST00000489463 | Ncrna_pseudogene:scRNA_pseudogene chromosome:GRCh37:1:64121426:64121718:1 | -1.08 | 8.5 | 5.7E-03 |
| 7926670 | ENST00000430957 | cDNA:known chromosome:GRCh37:10:23425901:23426107:1 | -1.08 | 8.6 | 5.2E-03 |
| 8098167 | C4orf39 | Chromosome 4 open reading frame 39 | -1.08 | 8.6 | 5.4E-03 |
| 7937474 | NS3BP | NS3BP | -1.08 | 8.2 | 6.3E-03 |
| 7935690 | ENST00000471360 | Ncrna_pseudogene:Mt_tRNA_pseudogene chromosome:GRCh37:10:101817589:101817658:-1 | -1.08 | 7.6 | 8.5E-03 |
| 8090366 | UROC1 | Urocanase domain containing 1 | -1.08 | 7.5 | 8.8E-03 |
| 8103753 | MORF4 | Mortality factor 4 | -1.09 | 8.0 | 7.2E-03 |
| 8130939 | DLL1 | Delta-like 1 (Drosophila) | -1.09 | 7.7 | 8.0E-03 |
| 8019437 | CCDC57 | Coiled-coil domain containing 57 | -1.09 | 8.0 | 7.0E-03 |
| 7966596 | IQCD | IQ motif containing D | -1.10 | 13.5 | 6.3E-04 |
| 7974695 | ENST00000480540 | cDNA:pseudogene chromosome:GRCh37:14:59261372:59261747:1 | -1.10 | 8.3 | 6.0E-03 |
| 8175815 | PNCK | Pregnancy up-regulated non-ubiquitously expressed CaM kinase | -1.10 | 9.6 | 3.3E-03 |
| 8030292 | DKKL1 | Dickkopf-like 1 | -1.10 | 8.5 | 5.6E-03 |
| 7997533 | OSGIN1 | Oxidative stress induced growth inhibitor 1 | -1.11 | 7.7 | 8.0E-03 |
| 8067671 | SRMS | Crc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | -1.11 | 7.6 | 8.3E-03 |
| 7998929 | ENST00000470337 | Ncrna_pseudogene:tRNA_pseudogene chromosome:GRCh37:16:3220961:3221031:-1 | -1.12 | 7.3 | 9.7E-03 |
| 8017361 | ENST00000460492 | cDNA:pseudogene chromosome:GRCh37:17:60593682:60594128:-1 | -1.12 | 15.2 | 3.2E-04 |
| 7973900 | C14orf19 | Immunoglobulin (CD79A) binding protein 1 pseudogene | -1.13 | 12.8 | 8.4E-04 |
| 7950321 | UCP3 | Uncoupling protein 3 (mitochondrial, proton carrier) | -1.13 | 11.0 | 1.8E-03 |
| 7965838 | ENST00000411000 | Ncrna:snRNA chromosome:GRCh37:12:102190188:102190280:-1 | -1.15 | 9.1 | 4.2E-03 |
| 8113413 | NUDT12 | Nudix (nucleoside diphosphate linked moiety X)-type motif 12 | -1.16 | 9.2 | 4.0E-03 |
| 8175775 | MAGEA1 | Melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | -1.16 | 7.5 | 8.8E-03 |
| 7948667 | AHNAK | AHNAK nucleoprotein | -1.18 | 7.9 | 7.3E-03 |
| 7913252 | PINK1 | PTEN induced putative kinase 1 | -1.18 | 7.9 | 7.5E-03 |
| 8118974 | RPL10A | Ribosomal protein L10a | -1.19 | 7.8 | 7.7E-03 |
| 7979551 | PPP2R5E | Protein phosphatase 2, regulatory subunit B', epsilon isoform | -1.20 | 7.3 | 9.6E-03 |
| 7972021 | TBC1D4 | TBC1 domain family, member 4 | -1.21 | 8.2 | 6.4E-03 |
| 8106393 | F2R | Coagulation factor II (thrombin) receptor | -1.23 | 9.1 | 4.3E-03 |
| 7900597 | C1orf50 | Chromosome 1 open reading frame 50 | -1.24 | 10.5 | 2.3E-03 |
| 7903753 | GSTM2 | Glutathione S-transferase mu 2 (muscle) | -1.58 | 16.5 | 2.0E-04 |
| 7903765 | GSTM1 | Glutathione S-transferase mu 1 | -2.00 | 22.0 | 2.6E-05 |
*
Rows are sorted by decreasing fold-change in PTSD cases relative to non-PTSD comparison subjects.