Table 5.
Exons Significantly Dysregulated in Peripheral Blood Mononuclear Cells from the Full Sample of Eventual PTSD Cases at Post-Deployment.
| Transcript Cluster ID |
Gene Symbol | Gene Product | Accession Number |
F | p | Adjusted p |
q | Probesets (n) |
Dysregulated Probesets (n) |
Dysregulated Probeset ID+ |
|---|---|---|---|---|---|---|---|---|---|---|
| 7903765 | GSTM1 | Glutathione S-transferase mu 1 | NM_000561 | 7.8 | 1.1E-09 | 2.3E-05 | 2.3E-05 | 9 | 9 | 7903767 |
| 7954810 | LRRK2 | Leucine-rich repeat kinase 2 | NM_198578 | 2.6 | 2.8E-09 | 5.8E-05 | 2.9E-05 | 53 | 10 | 7954831 |
| 8158597 | GPR107 | G protein-coupled receptor 107 | NM_001136557 | 3.1 | 2.2E-07 | 4.4E-03 | 1.5E-03 | 27 | 5 | 8158617 |
| 8052443 | USP34 | Ubiquitin specific peptidase 34 | NM_014709 | 2.0 | 3.9E-07 | 7.9E-03 | 2.0E-03 | 80 | 4 | 8052505 |
| 8022767 | TRAPPC8 | Trafficking protein particle complex 8 | NM_014939 | 2.8 | 5.9E-07 | 1.2E-02 | 2.3E-03 | 31 | 2 | 8022775 |
| 8086008 | DYNC1LI1 | Dynein, cytoplasmic 1, light intermediate chain 1 | NM_016141 | 4.5 | 6.7E-07 | 1.4E-02 | 2.3E-03 | 13 | 1 | 8086013 |
| 8136662 | MGAM | Maltase-glucoamylase (alpha-glucosidase) | NM_004668 | 2.4 | 9.3E-07 | 1.9E-02 | 2.3E-03 | 46 | 1 | 8136700 |
| 8070467 | TMPRSS2 | Transmembrane protease, serine 2 | NM_001135099 | 4.2 | 9.6E-07 | 1.9E-02 | 2.3E-03 | 14 | 1 | 8070472 |
| 8059596 | TRIP12 | Thyroid hormone receptor interactor 12 | NM_004238 | 2.4 | 1.0E-06 | 2.0E-02 | 2.3E-03 | 43 | 2 | 8059600 |
| 8142307 | PNPLA8 | Patatin-like phospholipase domain containing 8 | NM_015723 | 3.9 | 1.1E-06 | 2.3E-02 | 2.3E-03 | 16 | 1 | 8142322 |
| 7978285 | ADCY4 | Adenylate cyclase 4 | NM_001198592 | 2.9 | 2.1E-06 | 4.3E-02 | 4.0E-03 | 26 | 2 | 7978294 |
| 8149986 | ZNF395 | Zinc finger protein 395 | NM_018660 | 3.9 | 2.6E-06 | 5.2E-02 | 4.3E-03 | 15 | 1 | 8149998 |
| 8058118 | KCTD18 | Potassium channel tetramerisation domain containing 18 | NM_152387 | 5.5 | 5.0E-06 | 0.10 | 7.8E-03 | 8 | 1 | 8058121 |
| 8010454 | RNF213 | Ring finger protein 213 | NM_020914 | 2.2 | 1.0E-05 | 0.21 | 1.5E-02 | 44 | 1 | 8010469 |
| 7946610 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma, 2 | NM_001418 | 2.8 | 1.5E-05 | 0.31 | 2.1E-02 | 24 | 1 | 7946612 |
| 7982904 | RTF1 | Rtf1, Paf1 | NM_015138 | 2.8 | 2.6E-05 | 0.52 | 3.3E-02 | 22 | 3 | 7982911 |
| 8079869 | RBM5 | RNA binding motif protein 5 | NM_005778 | 2.6 | 2.9E-05 | 0.58 | 3.4E-02 | 26 | 1 | 8079878 |
| 8076077 | DDX17 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | NM_006386 | 3.2 | 4.1E-05 | 0.84 | 4.5E-02 | 16 | 3 | 8076093 |
| 7968128 | PABPC3 | Poly(A) binding protein, cytoplasmic 3 | NM_030979 | 11.3 | 4.2E-05 | 0.85 | 4.5E-02 | 3 | 1 | 7968129 |
| 8172914 | HUWE1 | HECT, UBA and WWE domain containing 1 | NM_031407 | 1.7 | 5.0E-05 | 1.00 | 5.0E-02 | 90 | 5 | 8172940 |
| 7903777 | GSTM5 | Glutathione S-transferase mu 5 | NM_000851 | 4.7 | 5.2E-05 | 1.00 | 5.0E-02 | 8 | 3 | 7903782 |
| 8139896 | PMS2P4 | Postmeiotic segregation increased 2 pseudogene 4 | NR 022007 | 8.0 | 6.3E-05 | 1.00 | 5.8E-02 | 4 | 1 | 8139900 |
| 8076455 | RRP7A | Ribosomal RNA processing 7 homolog A (S. cerevisiae) | NM_015703 | 6.3 | 9.0E-05 | 1.00 | 7.5E-02 | 5 | 1 | 8076458 |
| 7996677 | NUTF2 | Nuclear transport factor 2 | NM_005796 | 4.9 | 1.0E-04 | 1.00 | 7.5E-02 | 7 | 2 | 7996683 |
| 8015642 | PSMC3IP | PSMC3 interacting protein | NM_016556 | 3.5 | 1.0E-04 | 1.00 | 7.5E-02 | 12 | 1 | 8015646 |
| 8058182 | FAM126B | Family with sequence similarity 126, member B | NM_173822 | 3.5 | 1.0E-04 | 1.00 | 7.5E-02 | 12 | 0 | - |
| 8029884 | SAE1 | SUMO1 activating enzyme subunit 1 | NR 027280 | 4.1 | 1.1E-04 | 1.00 | 7.5E-02 | 9 | 1 | 8029892 |
| 8096938 | LARP7 | La ribonucleoprotein domain family, member 7 | NM_016648 | 3.0 | 1.1E-04 | 1.00 | 7.5E-02 | 16 | 2 | 8096944 |
| 7965359 | ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | NM_001001323 | 2.5 | 1.1E-04 | 1.00 | 7.5E-02 | 24 | 1 | 7965379 |
| 8159984 | C9orf46 | Chromosome 9 open reading frame 46 | NM_018465 | 4.8 | 1.1E-04 | 1.00 | 7.5E-02 | 7 | 1 | 8159991 |
| 7965652 | CDK17 | Cyclin-dependent kinase 17 | NM_002595 | 2.8 | 1.2E-04 | 1.00 | 7.6E-02 | 18 | 1 | 7965654 |
| 8077858 | ATG7 | ATG7 autophagy related 7 homolog (S. cerevisiae) | NM_006395 | 2.8 | 1.2E-04 | 1.00 | 7.6E-02 | 18 | 1 | 8077874 |
| 7971602 | RCBTB1 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | NM018191 | 3.4 | 1.2E-04 | 1.00 | 7.6E-02 | 12 | 1 | 7971613 |
| 7971620 | KPNA3 | Karyopherin alpha 3 (importin alpha 4) | NM_002267 | 2.7 | 1.3E-04 | 1.00 | 7.8E-02 | 19 | 1 | 7971637 |
| 7956910 | CAND1 | Cullin-associated and neddylation-dissociated 1 | NM_018448 | 2.7 | 1.4E-04 | 1.00 | 7.8E-02 | 19 | 3 | 7956914 |
| 8002778 | MLKL | Mixed lineage kinase domain-like | NM_152649 | 3.3 | 1.4E-04 | 1.00 | 7.8E-02 | 13 | 1 | 8002781 |
| 8160213 | TTC39B | Tetratricopeptide repeat domain 39B | NM_152574 | 2.6 | 1.4E-04 | 1.00 | 7.8E-02 | 22 | 2 | 8160226 |
| 7962112 | CAPRIN2 | Caprin family member 2 | NM_001002259 | 2.5 | 1.5E-04 | 1.00 | 7.8E-02 | 24 | 1 | 7962123 |
| 7981068 | SERPINA1 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | NM_001002236 | 4.0 | 1.6E-04 | 1.00 | 8.1E-02 | 9 | 2 | 7981074 |
| 8103951 | ACSL1 | Acyl-CoA synthetase long-chain family member 1 | NM_001995 | 2.5 | 1.8E-04 | 1.00 | 9.3E-02 | 23 | 1 | 8103965 |
| 7999841 | SMG1 | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) | NM_015092 | 2.0 | 2.0E-04 | 1.00 | 1.0E-01 | 42 | 4 | 7999869 |
| 7933047 | CUL2 | Cullin 2 | NM_003591 | 2.5 | 2.1E-04 | 1.00 | 0.10 | 23 | 2 | 7933056 |
| 8017162 | RNFT1 | Ring finger protein, transmembrane 1 | NM_016125 | 3.6 | 2.2E-04 | 1.00 | 0.10 | 10 | 3 | 8017163 |
| 7967881 | MPHOSPH8 | M-phase phosphoprotein 8 | NM_017520 | 3.0 | 2.4E-04 | 1.00 | 0.11 | 14 | 1 | 7967895 |
| 7900426 | SMAP2 | Small ArfGAP2 | NM_022733 | 3.4 | 2.5E-04 | 1.00 | 0.11 | 11 | 1 | 7900432 |
| 7903893 | CD53 | CD53 molecule | NM_000560 | 3.3 | 2.5E-04 | 1.00 | 0.11 | 12 | 2 | 7903894 |
| 8078569 | GOLGA4 | Golgin A4 | NM_002078 | 2.2 | 2.6E-04 | 1.00 | 0.11 | 30 | 2 | 8078594 |
| 7967117 | OASL | 2′-5′-oligoadenylate synthetase-like | NM_003733 | 3.8 | 2.6E-04 | 1.00 | 0.11 | 9 | 3 | 7967123 |
| 7975416 | PCNX | Pecanex homolog (Drosophila) | NM_014982 | 2.1 | 2.7E-04 | 1.00 | 0.11 | 36 | 1 | 7975429 |
| 8179298 | CSNK2B | Casein kinase 2, beta polypeptide | NM_001320 | 3.6 | 2.8E-04 | 1.00 | 0.11 | 10 | 1 | 8179308 |
| 8143327 | PARP12 | Poly (ADP-ribose) polymerase family, member 12 | NM_022750 | 3.1 | 2.9E-04 | 1.00 | 0.11 | 13 | 2 | 8143336 |
| 8021496 | KIAA1468 | KIAA1468 | NM_020854 | 2.2 | 2.9E-04 | 1.00 | 0.11 | 31 | 4 | 8021504 |
| 8141846 | FBXL13 | F-box and leucine-rich repeat protein 13 | NM_145032 | 2.3 | 3.0E-04 | 1.00 | 0.12 | 25 | 4 | 8141865 |
| 7929677 | PI4K2A | Phosphatidylinositol 4-kinase type 2 alpha | NM_018425 | 3.3 | 3.2E-04 | 1.00 | 0.12 | 11 | 0 | - |
| 8088348 | FAM116A | Family with sequence similarity 116, member A | NM_152678 | 2.5 | 3.3E-04 | 1.00 | 0.12 | 20 | 2 | 8088366 |
| 7937363 | PKP3 | Plakophilin 3 | NM_007183 | 3.0 | 3.5E-04 | 1.00 | 0.13 | 14 | 2 | 7937370 |
| 8089785 | POPDC2 | Popeye domain containing 2 | NM_022135 | 3.7 | 3.6E-04 | 1.00 | 0.13 | 9 | 2 | 8089794 |
| 7967563 | UBC | Ubiquitin C | NM_021009 | 2.9 | 3.6E-04 | 1.00 | 0.13 | 14 | 2 | 7967584 |
| 8077171 | RABL2B | RAB, member of RAS oncogene family-like 2B | NM_001130921 | 3.0 | 3.7E-04 | 1.00 | 0.13 | 13 | 1 | 8077180 |
| 8112772 | AP3B1 | Adaptor-related protein complex 3, beta 1 subunit | NM_003664 | 2.2 | 3.7E-04 | 1.00 | 0.13 | 28 | 2 | 8112794 |
| 7997626 | KLHL36 | Kelch-like 36 (Drosophila) | NM_024731 | 4.7 | 3.9E-04 | 1.00 | 0.13 | 6 | 2 | 7997629 |
| 8043251 | PTCD3 | Pentatricopeptide repeat domain 3 | NM_017952 | 2.3 | 5.0E-04 | 1.00 | 0.16 | 24 | 0 | - |
| 8072170 | KREMEN1 | Kringle containing transmembrane protein | NM_032045 | 2.9 | 5.0E-04 | 1.00 | 0.16 | 14 | 4 | 8072173 |
*
Rows are sorted by increasing p-value for the interaction of diagnosis and exonID.
+
Exon probesets listed were the most significantly differentially expressed (per gene) between diagnostic groups. Information on the identities of all dysregulated exons for each gene can be obtained from the authors upon request.