Table 6. Annotations Enriched at Corrected Significance Levels among Differentially-Expressed Exons (p<0.0005) in Peripheral Blood Mononuclear Cells from the Full Sample of PTSD Cases at Post-Deployment*.
| DAVID Category | Term | Count (%) | Fold- Enrichment | P | Bonferroni- Corrected p | Gene Corresponding to Dysregulated Exon |
|---|---|---|---|---|---|---|
| INTERPRO | IPR011989:Armadillo-like helical | 7 (11.1%) | 14.9 | 6.5E-06 | 1.0E-03 | KIAA1468, AP3B1, PKP3, CAND1, TRIP12, KPNA3, LRRK2 |
| GOTERM_BP_FAT | GO:0009057∼macromolecule catabolic process | 12 (19.0%) | 4.5 | 4.2E-0.5 | 1.8E-0.2 | SAE1, SMG1, USP34, FBXL13, HUWE1, CAND1, ATG7, TRIP12, MGAM, CUL2, KLHL36, UBC |
| SP_PIR_KEYWORDS | Acetylation | 22 (34.9%) | 2.5 | 5.8E-05 | 7.9E-03 | EIF4G2, AP3B1, NUTF2, SMG1, HUWE1, PTCD3, CUL2, LARP7, UBC, ACSL1, KIAA1468, CSNK2B, SAE1, PABPC3, RTF1, ATG7, CAND1, KPNA3, RNF213, RBM5, MPHOSPH8, GSTM5 |
| GOTERM_BP_FAT | GO:0019941∼modification-dependent protein catabolic process | 10 (15.9%) | 5.1 | 1.0E-04 | 4.3E-02 | SAE1, USP34, FBXL13, HUWE1, CAND1, ATG7, TRIP12, CUL2, KLHL36, UBC |
| GOTERM_BP_FAT | GO:0043632∼modification-dependent macromolecule catabolic process | 10 (15.9%) | 5.1 | 1.0E-04 | 4.3E-02 | SAE1, USP34, FBXL13, HUWE1, CAND1, ATG7, TRIP12, CUL2, KLHL36, UBC |
|
| ||||||
| Reactome | Term | Count (%) | p | FDR- Corrected p | Gene Corresponding to Dysregulated Exon | |
|
| ||||||
| Class 1 MHC mediated antigen processing and presentation | 6 (9.9%) | 1.0E-04 | 1.5E-02 | SAE1,CUL2,ATG7,TRIP12,HUWE1,UBC | ||
*
Rows are sorted by increasing p-value for the enrichment of annotations.