Table 7. Exons Significantly Dysregulated in Peripheral Blood Mononuclear Cells from a Subset of PTSD Cases at Post-Deployment and Used in Predictive SVM Classifiers*.
| Transcript Cluster ID# | Gene Symbol | Gene Product | Interaction p | Exon ID | Fold-Change | F | p |
|---|---|---|---|---|---|---|---|
| 8096938 | LARP7 | La ribonucleoprotein domain family, member 7 | 7.2E-09 | 8096944 | 3.52 | 8.6 | 5.9E-03 |
| 8097148 | RNF213 | Ring finger protein 213 | 7.1E-11 | 8010469 | 3.06 | 9.6 | 3.8E-03 |
| 8086008 | DYNC1LI1 | Dynein, cytoplasmic 1, light intermediate chain 1 | 4.0E-10 | 8086013 | 3.06 | 7.9 | 8.3E-03 |
| 8134122 | PTCD3 | Pentatricopeptide repeat domain 3 | 1.6E-07 | 8043256 | 3.05 | 7.7 | 9.0E-03 |
| 8142307 | PNPLA8 | Patatin-like phospholipase domain containing 8 | 5.3E-09 | 8142322 | 2.87 | 9.3 | 4.4E-03 |
| 8172914 | DIDO1 | Death inducer-obliterator 1 | 3.7E-06 | 8067576 | 2.77 | 5.1 | 3.0E-02 |
| 8076455 | RRP7A | Ribosomal RNA processing 7 homolog A (S.cerevisiae) | 1.7E-05 | 8076458 | 2.74 | 12.8 | 1.1E-03 |
| 8158597 | GPR107 | G protein-coupled receptor 107 | 2.3E-10 | 8158617 | 2.74 | 11.5 | 1.8E-03 |
| 8054092 | CUL2 | Cullin 2 | 3.4E-06 | 7933056 | 2.71 | 11.9 | 1.5E-03 |
| 8105191 | KIAA1468 | KIAA1468 | 1.0E-07 | 8021504 | 2.71 | 11.1 | 2.1E-03 |
| 8045090 | ZC3H11A | Zinc finger CCCH-type containing 11A | 1.1E-05 | 7908985 | 2.67 | 6.5 | 1.6E-02 |
| 8056837 | TTC17 | Tetratricopeptide repeat domain 17 | 1.1E-06 | 7939453 | 2.63 | 6.3 | 1.7E-02 |
| 8079869 | NEK9 | NIMA (never in mitosis gene a)- related kinase 9 | 6.7E-06 | 7980282 | 2.62 | 8.4 | 6.4E-03 |
| 8079869 | RBM5 | RNA binding motif protein 5 | 1.5E-08 | 8079878 | 2.62 | 8.9 | 5.3E-03 |
| 8105191 | PARP8 | Poly (ADP-ribose) polymerase family, member 8 | 1.6E-05 | 8105199 | 2.57 | 4.6 | 4.0E-02 |
| 8083523 | AQR | Aquarius homolog (mouse) | 2.6E-05 | 7987328 | 2.57 | 6.3 | 1.7E-02 |
| 8136662 | MGAM | Maltase-glucoamylase (alpha-glucosidase) | 5.1E-08 | 8136700 | 2.57 | 4.4 | 4.3E-02 |
| 8107375 | TRAPPC8 | Trafficking protein particle complex 8 | 6.8E-08 | 8022775 | 2.56 | 7.1 | 1.2E-02 |
| 8136662 | UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1 | 2.1E-06 | 8045104 | 2.53 | 10.7 | 2.5E-03 |
| 8169541 | XRN2 | 5′-3′ exoribonuclease 2 | 2.7E-05 | 8061333 | 2.46 | 6.4 | 1.6E-02 |
| 8103951 | ACSL1 | Acyl-CoA synthetase long-chain family member 1 | 1.2E-05 | 8103961 | 2.45 | 5.2 | 3.0E-02 |
| 8172914 | HUWE1 | HECT, UBA and WWE domain containing 1 | 1.3E-07 | 8172982 | 2.42 | 7.7 | 9.0E-03 |
| 8061324 | CAND1 | Cullin-associated and neddylation-dissociated 1 | 5.1E-06 | 7956914 | 2.42 | 8.1 | 7.4E-03 |
| 8160213 | TTC39B | Tetratricopeptide repeat domain 39B | 3.3E-06 | 8160226 | 2.37 | 10.2 | 3.0E-03 |
| 8107375 | YTHDC2 | YTH domain containing 2 | 9.5E-06 | 8107388 | 2.35 | 12.7 | 1.1E-03 |
| 8149986 | ZNF395 | Zinc finger protein 395 | 4.6E-08 | 8149998 | 2.32 | 8.1 | 7.4E-03 |
| 8076455 | CDK17 | Cyclin-dependent kinase 17 | 5.8E-06 | 7965654 | 2.25 | 8.2 | 7.2E-03 |
| 8149986 | USP34 | Ubiquitin specific peptidase 34 | 1.5E-10 | 8052505 | 2.20 | 7.7 | 9.0E-03 |
| 8092933 | SMG1 | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. ele | 5.0E-07 | 7994025 | 2.18 | 5.0 | 3.2E-02 |
| 8156321 | TMEM131 | Transmembrane protein 131 | 2.2E-05 | 8054124 | 2.18 | 5.6 | 2.3E-02 |
| 8158597 | GPR155 | G protein-coupled receptor 155 | 3.6E-06 | 8056852 | 2.15 | 6.7 | 1.4E-02 |
| 8086008 | ADAM10 | ADAM metallopeptidase domain 10 | 7.6E-06 | 7989240 | 2.10 | 5.1 | 3.0E-02 |
| 8092933 | ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 2.4E-05 | 8092954 | 2.10 | 5.0 | 3.1E-02 |
| 8051882 | DENND2D | DENN | 3.4E-06 | 7918493 | 2.07 | 5.7 | 2.3E-02 |
| 8156321 | SYK | Spleen tyrosine kinase | 2.0E-06 | 8156330 | 1.93 | 13.3 | 8.7E-04 |
| 8083523 | GMPS | Guanine monphosphate synthetase | 8.9E-06 | 8083535 | 1.83 | 5.9 | 2.1E-02 |
| 8134122 | AKAP9 | A kinase (PRKA) anchor protein (yotiao) 9 | 7.8E-07 | 8134144 | 1.81 | 8.3 | 6.9E-03 |
| 8160213 | TRIP12 | Thyroid hormone receptor interactor 12 | 1.2E-06 | 8059619 | 1.79 | 6.5 | 1.6E-02 |
| 8059596 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma, 2 | 7.3E-07 | 7946612 | 1.76 | 5.9 | 2.1E-02 |
| 8130151 | APC2 | Adenomatosis polyposis coli 2 | 3.6E-05 | 8024308 | 1.75 | 7.0 | 1.2E-02 |
| 8130151 | RAET1E | Retinoic acid early transcript 1E | 3.7E-05 | 8130160 | 1.74 | 8.1 | 7.4E-03 |
| 8076077 | CAPRIN2 | Caprin family member 2 | 6.6E-06 | 7962123 | 1.69 | 6.4 | 1.6E-02 |
| 8103951 | NUP88 | Nucleoporin 88kDa | 4.9E-05 | 8011838 | 1.68 | 5.6 | 2.3E-02 |
| 8078569 | MPHOSPH8 | M-phase phosphoprotein 8 | 1.9E-05 | 7967895 | 1.63 | 18.3 | 1.5E-04 |
| 8052443 | FAM175B | Family with sequence similarity 175, member B | 2.7E-05 | 7931218 | 1.61 | 6.8 | 1.3E-02 |
| 8097148 | KIAA1109 | KIAA1109 | 1.7E-05 | 8097151 | 1.59 | 7.7 | 9.1E-03 |
| 8169541 | DOCK11 | Dedicator of cytokinesis 11 | 1.4E-05 | 8169559 | 1.41 | 5.5 | 2.5E-02 |
|
| |||||||
| 8022767 | SMAP2 | Small ArfGAP2 | 3.0E-05 | 7900432 | -1.12 | 6.1 | 1.9E-02 |
| 8179298 | DDX17 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | 1.1E-06 | 8076093 | -1.12 | 5.6 | 2.4E-02 |
| 8067563 | MDM2 | Mdm2 p53 binding protein homolog (mouse) | 6.3E-07 | 7957003 | -1.16 | 5.5 | 2.5E-02 |
| 8096938 | SMG1 | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) | 2.7E-08 | 7999869 | -1.20 | 14.1 | 6.6E-04 |
| 8043251 | GSTM5 | Glutathione S-transferase mu 5 | 4.2E-05 | 7903782 | -1.57 | 18.5 | 1.4E-04 |
| 8078569 | GOLGA4 | Golgin A4 | 5.0E-06 | 8078597 | -1.62 | 5.2 | 2.9E-02 |
| 8142307 | LRPPRC | Leucine-rich PPR-motif containing | 5.6E-07 | 8051896 | -1.77 | 10.4 | 2.8E-03 |
| 8179298 | CSNK2B | Casein kinase 2, beta polypeptide | 2.3E-05 | 8179308 | -1.83 | 7.8 | 8.4E-03 |
| 8024306 | GSTM1 | Glutathione S-transferase mu 1 | 4.5E-09 | 7903772 | -2.52 | 21.4 | 5.3E-05 |
*
Rows are sorted by decreasing fold-change in eventual PTSD cases relative to non-PTSD comparison subjects.
#
Exons of Transcript Cluster IDs in bold comprised the optimal 20-probe SVM classifier of eventual PTSD status identified by training and testing in independent samples.