Table 8. Annotations Enriched at Corrected Significance Levels among Dysregulated Transcripts across Studies Comparing PTSD Cases and Comparison Subjects.
DAVID Category | Term | Count (%) | Fold- Enrichment |
p | Bonferroni- Corrected p |
Gene Corresponding to Dysregulated Exon |
---|---|---|---|---|---|---|
GOTERM_BP_FAT | GO:0001775∼cell activation | 15 (8.1%) | 5.1 | 1.2E-06 | 2.1E-03 | BLM, SWAP70, STAT5B, KLRK1, MINK1, PF4, IGF2, SLAMF1, TGFB1, AZU1, CCND3, C14ORF19, TREML1, F2R, CD7 |
GOTERM_BP_FAT | GO:0009611∼response to wounding | 19 (10.2%) | 3.5 | 6.6E-06 | 1.1E-02 | LIPA, CCR1, STAT5B, CXCR1, PF4, IGF2, SOD1, CCL5, DTNBP1, TGFB1, GP9, AZU1, ORM1, CX3CR1, CTSB, PLA2G4C, TREML1, KDM6B, F2R |
GOTERM_CC_FAT | GO:0030141∼secretory granule | 10 (5.4%) | 5.7 | 5.9E-05 | 1.3E-02 | AZU1, SPAG8, PPBP, CPA3, PF4, SPARC, TREML1, RACGAP1, TGFB1, GP9 |
GOTERM_BP_FAT | GO:0001817∼regulation of cytokine production | 11 (5.9%) | 6.0 | 1.5E-05 | 2.5E-02 | AZU1, IL18, TIA1, STAT5B, KLRK1, IGF2, PF4, TRIM16, SOD1, TGFB1, F2R |
GOTERM_CC_FAT | GO:0031091∼platelet alpha granule | 6 (3.2%) | 11.0 | 2.0E-04 | 4.1E-02 | PPBP, PF4, SPARC, TREML1, TGFB1, GP9 |
GOTERM_CC_FAT | GO:0000323∼lytic vacuole | 10 (5.4%) | 4.9 | 2.0E-04 | 4.2E-02 | AZU1, LAPTM5, LIPA, MMD, IFI30, CPA3, CTSC, CTSB, ASAH1, GBA |
GOTERM_CC_FAT | GO:0005764∼lysosome | 10 (5.4%) | 4.9 | 2.0E-04 | 4.2E-02 | AZU1, LAPTM5, LIPA, MMD, IFI30, CPA3, CTSC, CTSB, ASAH1, GBA |
KEGG_PATHWAY | hsa04060:cytokine-cytokine receptor interaction | 13 (7.0%) | 3.2 | 5.0E-04 | 4.5E-02 | TNFRSF21, IL18R1, IL18, CCR1, CXCR1, PF4, CCL5, TGFB1, PPBP, CX3CR1, CSF2RB, IL2RG, IL3RA |
GOTERM_MF_FAT | GO:0019955∼cytokine binding | 8 (4.3%) | 7.0 | 1.4E-04 | 4.9E-02 | IL18R1, CCR1, CX3CR1, CSF2RB, CXCR1, IL2RG, TRIM16, IL3RA |
| ||||||
Reactome | Term | Count (%) | p | FDR-corrected p | Gene Corresponding to Dysregulated Exon | |
| ||||||
Cytokine-cytokine receptor interaction | 13 (7.0%) | 1.0E-05 | 3.0E-03 | IL18,TGFB1,PPBP,CX3CR1,CCL5,IL3RA,CXCR1,CSF2RB,TNFRSF21, CCR1,PF4,IL2RG,IL18R1 | ||
Lysosome | 7 (3.8%) | 3.0E-04 | 3.5E-02 | NAPSA,LAPTM5,ASAH1,CTSC,CTSB,GBA,LIPA | ||
Interleukin signaling pathway | 5 (2.7%) | 3.0E-04 | 4.7E-02 | IL16,IL18,STAT5B,IL3RA,CXCR1 |