Skip to main content
. Author manuscript; available in PMC: 2014 Oct 16.
Published in final edited form as: JAMA Neurol. 2013 Nov;70(11):1403–1410. doi: 10.1001/jamaneurol.2013.3849

Figure 1. Pedigrees of Family F297 Carrying c.1160C>T, p.P387L Mutation, Family F523 Carrying c.1142C>T, p.A381V Mutation, Family FR1324 Carrying c.1175C>T, p.P392L Mutation, and Family F480 Carrying c.98C>T, p.A33V Mutation.

Figure 1

The individuals are represented by diamonds for confidentiality. The probands are indicated by arrows. The black diamonds indicate individuals with a behavioral variant of frontotemporal dementia; the gray diamonds indicate individuals with dementia with no clinical information; and the white diamonds indicate nonsymptomatic individuals. The ages of individuals (in years) are indicated at onset of frontotemporal dementia (FTD), at onset of Paget disease of bone (PDB), at onset of amyotrophic lateral sclerosis (ALS), at onset of unspecified dementia (D), at onset of parkinsonism (P), and at death (AD), along with the current ages of alive individuals (A) and genotypes. In family F297, individuals 009 and 013, who did not carry the mutation, had no neurological symptoms at 80 and 85 years of age, respectively.

aDNA samples are available.