Table 4. Logistic Regression Analysis of Factors Associated with SVR a.
| Variable | No. | Univariate analysis, OR (95%CI) | P Value | Multivariate analysis b, OR (95%CI) | P Value |
|---|---|---|---|---|---|
| Gender | 178 | ||||
| Female | 1 | ||||
| Male | 1.115 (0.597-2.082) | 0.733 | |||
| Smoking history | 106 | ||||
| No | 1 | ||||
| Yes | 0.894 (0.346-2.311) | 0.818 | |||
| Drinking history | 108 | ||||
| No | 1 | ||||
| Yes | 0.775 (0.291-2.063) | 0.609 | |||
| GGT-Ⅱ | 86 | ||||
| − | 1 | ||||
| + | 0.816 (0.261-2.556) | 0.727 | |||
| HCV genotype | 92 | ||||
| 1b | 1 | ||||
| 2a/3a | 3.556 (1.174-10.765) | 0.044 | - | - | |
| HCV-RNA virus load | 160 | ||||
| HCV-RNA > 400 000IU/mL | 1 | ||||
| HCV-RNA < 400 000IU/mL | 1.044 (0.513-2.124) | 0.906 | |||
| rs8099917 | 112 | ||||
| TG/GG | 1 | ||||
| TT | 1.345 (0.427-4.237) | 0.612 | |||
| HCV-RNA, log IU/mL | 160 | 1.000 (1.000-1.000) | 0.420 | ||
| Age, y | 171 | 0.958 (0.929-0.987) | 0.005 | 0.997 (0.942-1.056) | 0.923 |
| ALT, U/L | 113 | 1.002 (0.999-1.005) | 0.188 | ||
| AST, U/L | 110 | 1.000 (0.996-1.004) | 0.993 | ||
| DBIL, umol/L | 113 | 0.959 (0.911-1.010) | 0.115 | ||
| TBIL, umol/L | 113 | 0.975 (0.948-1.002) | 0.072 | ||
| AFP, ng/mL | 95 | 1.000 (0.999-1.001) | 0.567 | ||
| AFU, U/L | 89 | 1.001 (0.999-1.002) | 0.373 | ||
| PT, s | 113 | 0.780 (0.631-0.965) | 0.022 | 0.967 (0.643-1.456) | 0.874 |
| PLT, × 10 9 /L | 113 | 1.004 (0.998-1.010) | 0.162 | ||
| ALP, U/L | 112 | 1.006 (0.996-1.016) | 0.213 | ||
| ALB, g/L | 112 | 1.188 (1.086-1.300) | 0.000 | 1.223 (1.046-1.430) | 0.011 |
| CHO, mmol/L | 82 | 2.078 (1.224-3.531) | 0.007 | 1.424 (0.753-2.694) | 0.277 |
| TG, mmol/L | 82 | 1.300 (0.907-1.863) | 0.153 |
a Abbreviations: GGT-Ⅱ, γ-glutamyl transferase isoenzymes Ⅱ; ALT, alanine aminotransferase; AST, aspartate aminotransferase; DBIL, direct bilirubin; TBIL, total bilirubin; AFP, alpha fetoprotein; AFU, α-L-fucosidase; PT, prothrombin time; PLT, platelet; ALP, alkaline phosphatase; ALB, albumin; CHO, cholesterol; TG, triglyceride; OR, odds ratio; CI, confidence interval.
b Multivariate analysis was performed with factors significantly associated with SVR by univariate analysis except for HCV genotype because of its many missing values in multivariate analysis. Finally, multivariate analysis was performed in 82 patients.