TABLE 4.
Summary of LSMMG-induced effects on microbial physiology
| Physiological effect induced by LSMMG | Bacterial species | Reference(s) |
|---|---|---|
| Altered production of secondary metabolites | ||
| Production inhibited | ||
| Cephalosporin | Streptomyces clavuligerus | 29 |
| Microcin B 17 | Escherichia coli | 28 |
| Rapamycin | Streptomyces hygroscopicus | 26 |
| Glycerol or glucose repression inhibited in RWV (not specific to LSMMG) | ||
| Gramicidin S (glycerol) | Bacillus brevis | 30 |
| Microcin B17 (glucose) | Escherichia coli | 27 |
| Increased extracellular accumulation | ||
| Microcin B17 | Escherichia coli | 28 |
| Rapamycin | Streptomyces hygroscopicus | 26 |
| Increased virulence in murine model of infection (decreased LD50, shortened host time to death, increased liver and spleen colonization) | Salmonella enterica serovar Typhimurium | 81 |
| Altered stress resistance | ||
| Increased ethanol stress resistance | Escherichia coli | 37 |
| Increased acid, osmotic, and thermal stress resistance | Salmonella enterica serovar Typhimurium | 81, 106 |
| Decreased oxidative stress (H2O2) resistance | Salmonella enterica serovar Typhimurium | 106 |
| Increased survival within J774 macrophages | Salmonella enterica serovar Typhimurium | 81, 106 |
| Decreased generation time in M9 minimal medium | Salmonella enterica serovar Typhimurium | 106 |
| Global alteration of gene expression (LSMMG regulon) | Salmonella enterica serovar Typhimurium | 107 |
| Saccharomyces cerevisiae | 52 |