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Immunohistochemistry results of highly atrophic fibers
| Protein | Gene | DM2 | DM1 |
|---|---|---|---|
| MyHC-IIa | MYH2 | +++ | +++ |
| MyHC-beta | MYH7 | (+) | +++ |
| MyHC-pn | MYH8 | +++ | +++ |
| MyHC-emb | MYH3 | (+) | (+) |
| fTnT | TNNT3 | ++ | ++ |
| NCAM | NCAM1 | ++ | + |
| Myogenin | MYOG | (+) | (+) |
| Vimentin | VIM | (+) | + |
Protein expression: (+), in <1% of highly atrophic fibers; +, in 1–10%; ++, in 30–50%; +++, in >75%. The results indicate how many fibers of the highly atrophic fibers pool expressed each given antigen in DM2 (n = 20) and DM1 (n = 5) muscle biopsies
