Table 1. Group 2 (non-EIACD). Iressa and Acute RT Toxicity. Reported as Definitely, Probably, or Possibly Related to Treatment.
The most common side-effects of gefitinib in combination with radiation were dermatologic, gastrointestinal, and fatigue.
| 250 mg (n=6) Grade | 500 mg (n=136) Grade | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 5 | |
| Allergy/Immunology | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| Auditory/Hearing | 0 | 0 | 0 | 0 | 3 | 5 | 0 | 0 | 0 |
| Blood/Bone marrow | 4 | 1 | 0 | 0 | 48 | 17 | 7 | 1 | 0 |
| Cardiovascular (arrhythmia) | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 0 | 0 |
| Cardiovascular (general) | 1 | 0 | 0 | 0 | 8 | 9 | 10 | 2 | 0 |
| Coagulation | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
| Constitutional symptoms | 3 | 1 | 0 | 0 | 49 | 48 | 7 | 5 | 0 |
| Dermatology/Skin | 2 | 0 | 2 | 0 | 40 | 62 | 17 | 2 | 0 |
| Gastrointestinal | 0 | 3 | 0 | 0 | 40 | 48 | 17 | 4 | 1 |
| Hemorrhage | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 2 | 0 |
| Hepatic | 1 | 3 | 1 | 0 | 17 | 19 | 23 | 5 | 0 |
| Infection/Febrile Neutropenia | 0 | 0 | 0 | 0 | 6 | 3 | 5 | 1 | 0 |
| Metabolic/Laboratory | 2 | 0 | 1 | 0 | 19 | 7 | 9 | 1 | 0 |
| Musculoskeletal | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 0 | 0 |
| Neurology | 0 | 0 | 0 | 1 | 11 | 13 | 12 | 5 | 0 |
| Ocular/Visual | 0 | 1 | 0 | 0 | 6 | 7 | 0 | 0 | 0 |
| Pain | 0 | 0 | 0 | 0 | 19 | 16 | 1 | 0 | 0 |
| Pulmonary | 0 | 0 | 0 | 0 | 4 | 4 | 6 | 2 | 0 |
| Renal/Genitourinary | 0 | 1 | 0 | 0 | 19 | 2 | 2 | 1 | 0 |
|
| |||||||||
| Worst Non Hematological | 1 (17%) | 2 (33%) | 2 (33%) | 1 (17%) | 7 (5%) | 41 (30%) | 63 (46%) | 23 (17%) | 1 (1%) |
|
| |||||||||
| Worst Overall | 1 (17%) | 2 (33%) | 2 (33%) | 1 (17%) | 6 (4%) | 41 (30%) | 63 (46%) | 24 (18%) | 1 (1%) |