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. Author manuscript; available in PMC: 2014 Oct 16.
Published in final edited form as: Subcell Biochem. 2014;70:129–149. doi: 10.1007/978-94-017-9050-5_7

Figure. 7.6. Representation of RA and DZNep effects on apoptosis regulation in human colon cancer cells.

Figure. 7.6

Retinoic acid treatment promotes TRAIL-related apoptosis in RARβ/RARγ–positive HT29 cells, but not in SW480 cells which express only low levels of RARβ/RARγ. The functional depletion of PRC2 by either inhibition with DZNep or by knockdown of SUZ12 increases TRAIL-mediated apoptosis in both HT29 and SW480 cell lines. In this scenario the PRC2-mediated repression is alleviated, thereby activating TNFRSF10 even in the absence of RARβ/RARγ.