. Author manuscript; available in PMC: 2014 Oct 16.

Published in final edited form as: Qual Life Res. 2014 Mar 7;23(7):1997–2013. doi: 10.1007/s11136-014-0656-1

Table 4.

Biological Pathways, Candidate Genes and Molecular Markers in Positive Emotional Functioning

Quality of Life Domains	Biological Pathways^*	Candidate genes	Biomolecular markers	Literature

Positive affect	-NR-	-NR-	-NR-	• (176, 177)

	• Dopaminergic system (ventral tegmental area)	• COMT, OPRM1	• CART	• (178)

	• Serotonergic synapse	• SLC6A4 (5-HTTLPR), MAOA	-NR-	• (179–181)

	• Neuroactive ligand-receptor interaction	-NR-	• Oxytocin	• (178)

	• Adipocytokine signaling pathway	• NPY	• Neuropeptide Y	• (178)

	• Cytokine-cytokine receptor interaction
	◆ pro-inflammatory	• TNF-α	• TNF-α	• (17)

Emotional appraisal	• Serotonergic synapse	• SLC6A4 (5-HTTLPR)	-NR-	• (182)

Biological pathways are according to KEGG (Kyoto Encyclopaedia of Genes and Genomes), http://www.genome.jp/kegg/ or Genecards, http://www.genecards.org/

Note: References are included in Supplementary Material 2: References to Tables 1–7.

NR: the relevant information was not reported

?: the relevant biological pathway could not be identified