. Author manuscript; available in PMC: 2014 Oct 16.

Published in final edited form as: Qual Life Res. 2014 Mar 7;23(7):1997–2013. doi: 10.1007/s11136-014-0656-1

Table 6.

Biological Pathways, Candidate Genes and Molecular Markers in Overall Quality of Life

Quality of Life Domains	Biological Pathways^*	Candidate genes	Biomolecular markers	Literature

*Overall Quality of Life*	• DNA repair pathway	• MGMT	-NR-	• (9)

	• Cytokine-cytokine receptor interaction
	◆ pro-inflammatory	• IL-6	• IL-6	• (17)
	◆ inflammation	-NR-	• CRP, neopterin	• (4)

	• Metabolic pathway	• TYMS, UGT1A1	-NR-	• (8)

	• Serotonergic synapse	• TPH1	• tryptophan	• (2, 4)

Biological pathways are according to KEGG (Kyoto Encyclopaedia of Genes and Genomes), http://www.genome.jp/kegg/ or Genecards, http://www.genecards.org/

Note: References are included in Supplementary Material 2: References to Tables 1–7.

NR: the relevant information was not reported

?: the relevant biological pathway could not be identified