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. 2014 Oct 7;20:1850–1857. doi: 10.12659/MSM.891340

Figure 2.

Figure 2

miR-150 targets PDCD4 in MIBC cells. (A) Schematic of the broadly-conserved miR-150 target site in the human PDCD4 3′UTR. (B) Inverse relationship between miR-150 expression and PDCD4 protein levels. (C) miR-150 inhibitor increases PDCD4 protein expression in MIBC cells. (D, E) miR-150 suppresses the luciferase activity linked to the 3′UTR of PDCD4 with a Renilla luciferase reporter used for normalization. Data were obtained from three independent experiments, and the mean of the results from (D) pMir-control-transfected SV-HUC-1 cells and (E) pMir-control-transfected HEK293T cells were set at 100%. * p<0.01.