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. 2014 Sep;10(3):146–157.

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© Mark J. Hamblin et al. Licensee Master Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A, MIP 1-α protein by ELISA in MH-S alveolar macrophages treated with simultaneous administration of LMW HA (250 μg/ml) and varying doses of lovastatin (0, 1, 5, 10, 20, 30, and 40 μM). Lovastatin significantly inhibited MIP 1-α production with an IC50 noted at a dose of 5 μM (p=0.001); B, MIP 1-α protein by ELISA in Thioglycollate derived peritoneal macrophages treated with simultaneous administration of LMW HA (250 μg/ml) and lovastatin (20 μM). Lovastatin significantly inhibited MIP 1-α production; C-E, KC, RANTES and TNF-α protein by ELISA in MH-S alveolar macrophages treated with simultaneous administration of LMW HA (250 μg/ml) and lovastatin (20 μM). Lovastatin significantly inhibited KC (p=0.005), and RANTES (0.009) but not TNF-α expression; F, MH-S Cells were stimulated with vehicle, LMW HA (250 μg/ml) alone or with simultaneous administration of lovastatin (20 μM) or lovastatin (20 μM) and mevonalate (500 μM). MIP 1-α mRNA expression was measured by Northern Blot analysis. Lovastatin significantly inhibited LMW HA induction of MIP 1-α DNA, and the addition of mevonalate did not restore MIP 1-α mRNA expression.