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MH-S alveolar macrophages were simultaneously treated with pravastatin (20 μM) and LMW HA (250 μg/ml), and cytokine production was measured in cultured cell supernatents by ELISA. Simultaneous treatment with pravastatin was unable to attenuate the up-regulation of LMW HA induced cytokines (A. MIP 1-α, B. RANTES, C. KC, and D. TNF-α).
