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. 2014 Oct 16;10(10):e1004687. doi: 10.1371/journal.pgen.1004687

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© 2014 Zhu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Epidermal stratification was promoted in FGF7/FGF10 proteins treated and organ-cultured skin of Gpr177^K14 mutant. Immunostaining using antibodies against KRT10 (green), KRT5 (red), and p63(green)shows that supplemented FGF7/FGF10 proteins in culture medium have no effect on epidermal stratification of wild type controls. Immunostaining on KRT1 and KRT10 for spinous layer, KRT5 for basal layer, and p63 shows that hypoplastic development of epidermis in the Gpr177^K14 mutant skin is significantly attenuated by exogenously supplied FGF7 and FGF10 in organ culture. Note an increase in numbers of both BrdU incorporated KRT5 cells and p63 expressing cells in FGF7/FGF10 treated skin explants from Gpr177^K14 mice. ep: epidermis; d: dermis. Bars: 50 µm. (B) Proposed model for a genetic hierarchy of WNT-BMP-FGF7/FGF10 signaling axis in regulating the embryonic epidermal stratification.