Table 2. Molecular clock model output.
Molecular clock | Population model prior | AICM++ | Mean substitution rate (95% HPD) | TMRCA Grenadian strains* | Substitute rate Grenadian branch |
Strict | Bayesian skyline | 28430 | 3.26×10−4 (2.49–4.04×10−4) | 16.4 yrs ago (8.6–25.1) | 3.26×10−4 (2.49–4.04×10−4) |
Strict | Constant | 28440 | 2.78×10−4 (1.96–3.57×10−4) | 23.4 yrs ago (14.6–34.8) | 2.78×10−4 (1.96–3.57×10−4) |
Uncorrelated lognormal | Bayesian skyline | 28360 | 3.99×10−4 (2.88–5.15×10−4) | 11.6 yrs ago (5.5–23.0) | 5.09×10−4 (2.99–7.40×10−4) |
Uncorrelated lognormal | Constant | 28370 | 3.17×10−4 (2.01–4.33×10−4) | 22.7 yrs ago (12.6–37.8) | 4.36×10−4 (2.38–6.94×10−4) |
* years since most recent strains (2013),
AICM is an analogue of Akaike's information criterion estimated through Markov Chain Monte Carlo simulation using the method-of-moments estimator [33]. Lower values indicate better model fit.