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. 2014 Oct 16;8(10):e3268. doi: 10.1371/journal.pntd.0003268

Figure 3. Protective efficacy of VMP001 in Aotus monkeys challenged intravenously with P. vivax Brazil VII strain post primary and rechallenge.

Figure 3

Monkeys were immunized with either 15 µg or 50 µg of VMP001. Control monkeys were immunized with 50 µg of P. falciparum LSA-1 (PfLSA-1). All antigens were formulated with Montanide ISA 720 and CpG 10104. Kaplan-Meier survival curves represent percentage of uninfected monkeys over time. Vaccine Efficacy was calculated as a ratio between the vaccinated and control groups (see results). 3A. Six weeks following the third immunization, all monkeys were challenged intravenously with 10,000 P. vivax Brazil VII parasites. 3B. Eight weeks after the primary challenge, monkeys were rechallenged with 15,000 P. vivax Brazil VII parasites.