Table 6. Sensitivity of anti-DENV IgM compared to IgM reference test in acute and convalescent samples.
Acute | Convalescent | |||||||
Tests | Positive | Total n = 56 | Sensitivity* (CI95) | Positive | Total n = 168 | Sensitivity* (CI95) | ||
IgM | ELISA | Venture | 55 | 56 | 98% (95–100) | 160 | 165¶ | 97% (94–100) |
RT | Abon | 67 | n = 112 107¶ | 63% (53–72) | 187 | n = 336 334¶ | 56% (51–61) | |
CTK | 51 | 112 | 46% (36–55) | 178 | 334¶ | 53% (48–59) | ||
Orgenic | 100 | 112 | 95% (90–99) | 250 | 255¶ | 82% (78–87) | ||
SD duo IgM | 106 | 112 | 89% (84–95) | 210 | 255¶ | 98% (96–100) |
Sensitivity of dengue anti-DENV IgM compared to IgM reference test in primary and secondary DENV infection status.
*Comparison to anti-DENV IgM reference positive samples.
Number of samples tested differed to total number due to either duplicates for RDTs, invalid test or equivocal result.
Acute is days post onset of fever (DPO) of 0–5 days, Convalescent is DPO = 6–14.
Primary = 1 DENV infection, Secondary ≥2 DENV infections.
CI95 = 95% confidence interval.