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. 2014 Oct 7;10:825–839. doi: 10.2147/TCRM.S48920

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© 2014 Baldi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Mechanisms that trigger pulmonary arterial hypertension as targets for pharmacological treatments.

Note: Copyright © 2004, Massachusetts Medical Society. Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med. 2004;351(14): 1425–1436.1 Adapted with permission from The New England Journal of Medicine.

Abbreviations: ET, endothelin; PgI₂, prostaglandin I₂; ET_A, endothelin receptor A; ET_B, endothelin receptor B; cGMP, cyclic guanosine monophosphate; cAMP, cyclic adenosine monophosphate; PDE5, phosphodiesterase type-5.