Table 2.
Parameters with established importance for assessing disease severity, stability, and prognosis
| Better prognosis | Determinants of prognosis | Worse prognosis |
|---|---|---|
| No | Clinical evidence of RV failure | Yes |
| Slow | Rate of progression of symptoms | Rapid |
| Classes I, II | WHO functional class | Class IV |
| Longer | 6-minute walking distance | Shorter |
| Peak oxygen consumption >15 mL/minute/kg | Cardiopulmonary exercise testing | Peak oxygen consumption <12 mL/minute/kg |
| Normal or near normal | BNP/NT-pro-BNP plasma levels | Very elevated |
| No pericardial effusion | Echocardiographic findings | Pericardial effusion |
| RAP <8 mmHg and CI ≥2.5 L/minute/m2 | Hemodynamics | RAP >15 mmHg or CI ≤2.0 L/minute/m2 |
Abbreviations: RV, right ventricular; WHO, World Health Organization; BNP/NT-pro-BNP, brain natriuretic peptide/N-terminal fragment of pro-BNP; RAP, right atrial pressure; CI, cardiac index.