Table 1. Incubation times of different mouse lines intracerebrally inoculated with RML and 22L prions.
| Mouse lines | Protein expression levelsa | Incubation times (average ± standard deviation in days) | |||
| Full-length PrPC | Mutant PrP | RML | 22L | ||
| First experiment | Prnp0/+ | 0.5× | - | 393 ± 13 (7/7)b | 272±1 (5/5) |
| MHM2Δ23-88/Prnp0/+ | 0.5× | 4× | 347±16 (6/6) | 277±2 (7/7) | |
| MHM2Δ23-88/Prnp0/0 | - | 4× | >730 (5/5) | 538±29 (3/3) | |
| Second experiment | Prnp0/+ | 0.5× | - | 387±14 (13/13) | 261±1 (9/9) |
| MHM2Δ23-88/Prnp0/+ | 0.5× | 4× | 365±12 (14/14) | 265±8 (10/10) | |
| MHM2Δ23-88/Prnp0/0 | - | 4× | >672 (6/6) | 527±59 (7/7) | |
a
Expression levels of full-length PrPC or mutant PrP are compared with those of PrPC in wild-type mice (ref 10).
b
The numbers in parentheses indicate the number of diseased mice/the number of inoculated mice.