Table 1. Clinical characteristics associated with miR-200c expression in patients with breast cancer.
| miR-200c expressiona | |||||
| Clinical variable | n | Low expression (%) | High expression (%) | P | OR (95% CL) |
| Age at diagnosis | 0.17b | ||||
| < = 59 | 85 | 38 (22.1) | 47 (27.3) | ||
| > = 60 | 87 | 48 (27.9) | 39 (22.7) | ||
| Patient status | 0.242b | ||||
| Dead, breast cancer | 60 | 29 (16.9) | 31 (18.0) | ||
| Dead, other cause | 59 | 35 (20.3) | 24 (14.0) | ||
| Alive, no recurrence | 46 | 20 (11.6) | 26 (15.1) | ||
| Alive, recurrence | 7 | 2 (1.2) | 5 (2.9) | ||
| Histological grade | 0.002b | ||||
| I and II | 106 | 63 (37.8) | 43 (27.5) | Ref. | |
| III | 61 | 21 (12.6) | 40 (24.0) | 0.002 | 2.79 (1.45–5.37) |
| Histological stage | 0.045 | ||||
| I | 44 | 21 (12.7) | 23 (13.9) | Ref. | |
| II | 100 | 45 (27.2) | 55 (33.3) | 0.762 | 1.116 (0.548–2.272) |
| III and IV | 21 | 16 (9.7) | 5 (3.0) | 0.035 | 0.285 (0.089–0.915) |
| Histological type | 0.254b | ||||
| Ductal | 117 | 54 (32.3) | 63 (37.7) | ||
| Lobular | 31 | 19 (11.4) | 12 (7.2) | ||
| Other | 19 | 11 (6.6) | 8 (4.8) | ||
| Estrogen receptor | 0.866b | ||||
| Negative | 51 | 26 (15.7) | 25 (15.0) | ||
| Positive | 115 | 57 (34.3) | 58 (34.9) | ||
| Progesterone receptor | 0.21b | ||||
| Negative | 72 | 40 (24.1) | 32 (19.3) | ||
| Positive | 94 | 43 (25.9) | 51 (30.7) | ||
| Her2-status | 0.452b | ||||
| Negative | 133 | 67 (42.1) | 66 (41.5) | ||
| Positive | 26 | 11 (6.9) | 15 (9.4) | ||
| Triple negativity | 0.541b | ||||
| Yes | 29 | 16 (9.3) | 13 (7.6) | ||
| No | 143 | 70 (40.7) | 73 (42.4) | ||
| Local/distant recurrence | 0.185b | ||||
| Yes | 73 | 32 (18.7) | 41 (24.0) | ||
| No | 98 | 53 (31.0) | 45 (26.3) | ||
| Primary distant metastasis | 0.337b | ||||
| Yes | 60 | 27 (15.7) | 33 (19.2) | ||
| No | 112 | 59 (34.3) | 53 (30.8) | ||
| Luminal type A/B | 0.531b | ||||
| Luminal A (er+, Her2−, pr+) | 100 | 49 (45.4) | 51 (47.2) | ||
| Luminal B (er+, Her2+, pr−) | 8 | 3 (2.8) | 5 (46.3) | ||
Abbreviations: n, number of cases; Ref, reference category in the logistic regression analysis.
a
Low and high relative expression of miR-200c according to the median value.
b
P value assessed by chi-square test; other P values based on the logistic regression analysis.