Table 2. Distribution of CYP2C19*2, *3 and PON1 genotypes in clopidogrel responders and non-responders.
CYP2C19*2 (rs4244285) | ||||
Non-responders | Responders | Total | ||
Genotype | (n = 70) | (n = 141) | (n = 211) | p-value* |
GG (*1/*1) | 27 (38.6%) | 85 (60.3%) | 112 (53.1%) | 2.9×10−3 † |
GA (*1/*2) | 31 (44.3%) | 53 (37.6%) | 84 (35.8%) | 0.349 |
AA (*2/*2) | 12 (17.1%) | 3 (2.1%) | 15 (7.1%) | 1.6×10−4 † |
HWE p-value ‡ | 0.549 | 0.106 | 0.889 | - |
Allele frequency | ||||
Allele*2 (95%CI) | 0.39 (0.32–0.48) | 0.21 (0.16–0.26) | 0.27 (0.23–0.31) | 6.3×10−5 † |
* Comparison of genotype and allele frequencies between non-responders and responders.
Statistically significant difference at p<0.05.
p-value of Hardy-Weinberg equilibrium.