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. 2014 Oct 16;9(10):e110188. doi: 10.1371/journal.pone.0110188

Table 2. Distribution of CYP2C19*2, *3 and PON1 genotypes in clopidogrel responders and non-responders.

CYP2C19*2 (rs4244285)
Non-responders Responders Total
Genotype (n = 70) (n = 141) (n = 211) p-value*
GG (*1/*1) 27 (38.6%) 85 (60.3%) 112 (53.1%) 2.9×10−3
GA (*1/*2) 31 (44.3%) 53 (37.6%) 84 (35.8%) 0.349
AA (*2/*2) 12 (17.1%) 3 (2.1%) 15 (7.1%) 1.6×10−4
HWE p-value 0.549 0.106 0.889 -
Allele frequency
Allele*2 (95%CI) 0.39 (0.32–0.48) 0.21 (0.16–0.26) 0.27 (0.23–0.31) 6.3×10−5

* Comparison of genotype and allele frequencies between non-responders and responders.

Statistically significant difference at p<0.05.

p-value of Hardy-Weinberg equilibrium.