Table 3. Association between CYP2C19*2, *3, PON1 Q192R and clopidogrel resistance.
CYP2C19*2 (rs4244285) | ||||
Genotype | Crude OR (95%CI) | p-value | Adjusted OR (95%CI)† | p-value |
GG (*1/*1) | 1 | - | 1 | - |
GA (*1/*2) | 1.84 (0.99–3.42) | 0.053 | 2.30 (1.14–4.66) | 0.021 |
AA (*2/*2) | 12.59 (3.31–47.96) | <0.001* | 13.23 (2.87–60.88) | 0.001* |
Allele A (*2) | 2.57 (1.59–4.14) | <0.001* | 2.86 (1.63–5.03) | <0.001* |
* Risk is statistical significant when compared to the reference genotype at p-value<0.017.
Adjusted for diabetes, age, sex, history of smoking and platelet count.
Adjusted for concurrent *2 or *3 allele and covariates (diabetes, age, sex, history of smoking, and platelet count).