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. 2014 Oct 16;9(10):e111044. doi: 10.1371/journal.pone.0111044

Figure 4. Expression of CD25 and FoxP3 on CD8+ T cells before and after adjustment.

Figure 4

Representative dot plots show the expression of CD25 and FoxP3 on CD8+ T cells in the peripheral blood obtained from a single subject from each group (A). The original values associated with CD25 and FoxP3 expressed on CD4+T cells in peripheral blood from healthy nonsmokers (n = 20) and subjects with SCOPD (n = 23) and AECOPD (n = 21) were comprehensively analyzed (B). To eliminate the mixed effects of inflammatory factors, we calculated the ratios of original values to TNF-α (C) and IL-17 (D). The data are presented as the mean ± SEM, unless otherwise stated. *p<0.05 and **p<0.01. Activation index = CD8+CD25+/CD8+; Treg percentage = CD8+CD25+FoxP3+/CD8+; Treg index = CD8+CD25+FoxP3+/CD8+CD25+; Tc index = CD8+CD25+FoxP3−/CD8+CD25+; Pro-inflammatory index = Tc index/Treg index.