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. 2014 Oct 16;9(10):e110610. doi: 10.1371/journal.pone.0110610

Figure 4. Co-expression analysis of caspases and cholesterol genes in human brain and GBM.

Figure 4

A. Expression levels of the different caspases in GBM and in the normal brains. Box plots depicted in red mark tumors whereas blue was used for normal brain. mRNA levels of CASP1, CASP3, CASP4, CASP6, CASP7 and CASP8 were significantly augmented in tumor samples. p-value <2.2e-16. B. Correlations of expression levels between caspases and cholesterol genes in different brain and GBM samples in Cholesterol export, lipoproteins category. Data obtained were used to calculate the correlation values with the Pearson method. In the heat map positive values are displayed in blue and negative in dark green. The dendrograms displayed on the top are based on hierarchical clustering using the complete linkage method.