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. Author manuscript; available in PMC: 2014 Oct 16.
Published in final edited form as: Int J Cancer. 2013 Sep 23;134(5):1045–1054. doi: 10.1002/ijc.28448

Figure 3. PIAS3 regulates Bcl-xL and Noxa expression.

Figure 3

(A) A549 and H1299 cells were transfected with PIAS3 (P) or empty plasmid (V) or not transfected (C) for 24 h. Protein lysates were analyzed by western blotting for Bcl-2 family members. Two sets of experiments were used for these studies, each with its own loading control. (B) Synergy of PIAS3 with ABT-263. A549 cells were transfected with PIAS3 (P) or mock transfected (C) then incubated for 24 h in the absence or presence of 10 μM ABT-263 (A). Protein lysates were western blotted for caspase 9 cleavage.