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. Author manuscript; available in PMC: 2014 Oct 16.
Published in final edited form as: Int J Cancer. 2013 Sep 23;134(5):1045–1054. doi: 10.1002/ijc.28448

Figure 6. Proposed mechanism(s) of PIAS3-induced apoptosis in lung cancer cells.

Figure 6

PIAS3 acts through STAT3 dependent and independent pathways to disrupt Bcl-2 protein family binding equilibrium at the mitochondria (mito) and promote apoptosis. These effects are p53 independent. Puma is shown as one example of how p53 regulates mitochondrial apoptotic pathways.