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. 2014 Oct 16;9(10):e110542. doi: 10.1371/journal.pone.0110542

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© 2014 Ko et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The use of RAGE antibody (10 ng/ml pretreatment for 1 hour) to block AGE conjugation resulted in a significant increase in the ERK phosphorylation, MMP2, and MMP9 due to AGEs. Compared with AGEs treatment (#), RAGE antibody blocked ERK phosphorylation, MMP2, and MMP9 (A and B) as well as cell migration (C).