Table 5.
Correlation between SMN2 Copy Number and Ag1-CA and C212 Marker Alleles
|
No. of Marker Allelesa |
||||||
| PolymorphicMarker,Type of SMA,and SMN2Copy Number | 1 | 2 | 3 | 4 | 5 | % ofPatientsb |
| Ag1-CA: | ||||||
| Type I SMA: | ||||||
| 1 |
1 |
10 | 2 | |||
| 2 | 3 |
114 |
9 | 5 | 81 | |
| 3 | 1 | 9 |
27 |
|||
| Type II SMA: | ||||||
| 2 |
7 |
4 | 1 | |||
| 3 | 11 |
77 |
1 | 1 | 77 | |
| 4 | 1 | 6 |
1 |
|||
| Type III SMA: | ||||||
| 2 |
2 |
1 | ||||
| 3 | 3 |
28 |
7 | 64 | ||
| 4 | 5 | 11 |
19 |
|||
| C212: | ||||||
| Type I SMA: | ||||||
| 1 |
1 |
10 | 2 | |||
| 2 | 8 |
108 |
11 | 4 | 75 | |
| 3 | 1 | 8 |
27 |
1 | ||
| Type II SMA: | ||||||
| 2 | 1 |
6 |
4 | 1 | ||
| 3 | 26 |
60 |
2 | 62 | ||
| 4 | 2 | 5 |
1 |
|||
| Type III SMA: | ||||||
| 2 |
2 |
1 | ||||
| 3 | 6 |
28 |
4 | 63 | ||
| 4 | 4 | 13 |
18 |
|||
a
Underlined, boldfaced numbers represent those values where identical SMN2 copy number versus Ag1-CA/C212 alleles were found.
b
Percentage of patients with SMA with identical SMN2 copies and Ag1-CA/C212 alleles.