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. Author manuscript; available in PMC: 2015 Apr 16.
Published in final edited form as: Nature. 2014 Aug 3;514(7522):328–334. doi: 10.1038/nature13603

Figure 5. Unified view of glutamate receptor gating cycle.

Figure 5

a, Schematic summary of global conformational changes highlighting domain movements with channel opening and closure during the receptor gating cycle. The dashed lines over the open state indicate the shortening as a result of the corkscrew rotation that opens the channel. The differences observed between desensitized states of GluK2 and GluA2 are illustrated as variations of a common theme in which the LBD layer shifts to 4-fold symmetry with or without separation of the ATD dimer pairs.