Skip to main content
. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Aug 28;34(11):2495–2500. doi: 10.1161/ATVBAHA.114.303916

Table 2.

Continuous relations of primary tonometry variables with vascular calcification in the pooled FHS Third Generation and Offspring Cohorts without prevalent CVD (n=2920)

Tonometry
Measure		 Model Loge (TAC+1)
B±SE		 P value Loge (AAC+1)
B±SE		 P value Loge (CAC+1)
B±SE		 P value
CFPWV MV
MV+ SBP		 1.93±0.18
2.03±0.19		 <1.0*10−14
<1.0*10−14 		0.84±0.11
0.78±0.12		 8.0*10−14*
5.3*10−11* 		0.73±0.11
0.68±0.11		 5.5*10−12*
1.6*10−9*
Central pulse
pressure		 MV
MV+ SBP		 0.68±0.13
0.71±0.16		 1.8*10−7*
8.0*10−6* 		0.43±0.09
0.35±0.10		 1.4*10−7*
8.1*10−4* 		0.31±0.08
0.20±0.10		 2.7*10−4*
3.3*10−2*
Forward wave
amplitude		 MV
MV+ SBP		 0.63±0.12
0.61±0.14		 4.2*10−7*
1.3*10−5* 		0.24±0.09
0.12±0.09		 5.2*10−3*
1.9*10−1* 		0.26±0.08
0.17±0.09		 9.0*10−4*
4.9*10−2*
Augmentation
Index		 MV
MV+ SBP		 0.20±0.15
0.13±0.15		 1.7*10−1
3.9*10−1 		0.73±0.10
0.68±0.10		 <1.0*10−14*
6.4*10−13* 		0.23±0.09
0.17±0.09		 5.8*10−3
5.1*10−2

CFPWV: carotid-femoral pulse wave velocity. CAC: coronary artery calcium. TAC: thoracic aortic calcium. AAC: abdominal aortic calcium. MV: multivariable. Loge() represents the natural logarithm.

Multivariable models adjusted for age, sex, cohort, body mass index, height, heart rate, history of hypertension or lipid-lowering medications, total cholesterol/HDL, diabetes, and current smoking.

B±SE represents change in loge (calcification measure +1) per SD higher value for the tonometry variable.

*

p<0.05 for cohort-interaction