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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Oct 9;34(11):2378–2386. doi: 10.1161/ATVBAHA.114.303428

Figure 1. Primary structure of ERK5 and its regulation.

Figure 1

The N-terminus region with SUMO modification inhibits its own transactivation. After ERK5 kinase activation induced by MEK5 binding and TEY motif phosphorylation with de-SUMOylation of K6/K22 sites, ERK5 transcriptional activity at the C-terminus region is fully activated. In contrast athero-prone flow increases ERK5-SUMOylation and ERK5 S496 phosphorylation and inhibits ERK5 transcriptional activity.