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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Oct 9;34(11):2378–2386. doi: 10.1161/ATVBAHA.114.303428

Figure 5. Athero-prone flow increases p90RSK activation, leading to p90RSK-ERK5 association and ERK5 S496 phosphorylation, and subsequently decreases in ERK5 transcriptional activity.

Figure 5

At the basal level, inactive p90RSK inhibits the D-domain to bind ERK5. Once p90RSK is activated, the inhibition of the kinase domain is released and the D-domain of p90RSK associates with the ERK5 C-terminus domain97 and increases ERK5 S496 phosphorylation, which inhibits ERK5 transcriptional activity98. NTKD: NH2-terminal kinase domain, CTKD: COOH-terminal kinase domain, D-domain: NH2-terminal docking domain.