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. Author manuscript; available in PMC: 2015 Oct 15.
Published in final edited form as: Cancer Res. 2014 Aug 27;74(20):5723–5733. doi: 10.1158/0008-5472.CAN-13-2347

Figure 4. HMGB1 increases MDSC production of IL-10 and MDSC-macrophage crosstalk.

Figure 4

A, Co-cultures of 4T1-induced BALB/c MDSC and macrophages from tumor-free mice were incubated with or without ethyl pyruvate or glycyrrhizin, and the supernatants were assayed by ELISA for IL-10. B, MDSC from 4T1-tumor-bearing BALB/c and BALB/c IL-10−/− mice and peritoneal macrophages from tumor-free BALB/c mice were co-cultured and the supernatants were assayed by ELISA for IL-10. ND indicates non-detectable levels of protein. Data are from one of six and three independent experiments for panels A and B, respectively. p values were obtained by single-factor ANOVA.