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. Author manuscript; available in PMC: 2015 Oct 15.
Published in final edited form as: Cancer Res. 2014 Aug 27;74(20):5891–5902. doi: 10.1158/0008-5472.CAN-14-0184

Figure 1. β-catenin is highly expressed in cells with EGFR activating mutations.

Figure 1

(A) Immunoblots of extracts from cancer cell lines harboring wild type or mutant EGFR. (B) Confocal images of A549, NCI-H1650, NCI-H1975 cells stained with anti β-catenin antibody and visualized by Alexa Fluor 488. Scale Bar = 10 µm. (C) Immunohistochemical analysis of lungs isolated from a CCSP-rtTA mouse (I, II, III, IV) and lung tumors from an EGFR-L858R (LR)-T790M (TM) (EGFR-LR-TM)/CCSP-rtTA double transgenic mouse (V, VI, VII, VIII). Both animals were sacrificed after 20 weeks of doxycycline administration. Scale bar = 50 µm.