FIGURE 1.

A, An OCT image of a donor kidney that received mannitol 15 min or less before clamping the renal artery. The black holes (indicated by the small white arrows) represent open tubules just under the kidney capsule. B, An OCT image of a donor kidney that received mannitol 30 min or more before clamping the renal artery. There are no open tubules in B because of occluding of the tubule lumens with swollen cells. The patient receiving the donor kidney seen in A exhibited a return to normal serum creatinine levels within 2 days, whereas the patient receiving the donor kidney seen in B did not recover to within normal serum creatinine values (i.e., <1.4 mg/dL) until nearly two weeks after transplant. The black brackets indicate the kidney connective tissue capsule, whereas the white arrows indicate a layer of Tegaderm. Bars= 500 μM.