Figure 1.

Schematic of the 2.1-mb MCPH1 critical region. Microsatellite markers are in boldface type. An asterisk (*) denotes flanking markers for the ancestral haplotype. Sequenced BAC clones are shown as horizontal lines, and end-sequenced BAC clones as horizontal lines with blackened circles at the ends. The prefix “AC” denotes a novel microsatellite marker. Marker content determined by PCR (or electronically by BLAST) is indicated by vertical lines. NT = STS not tested against clone. The two genes in the critical region are shown, with their directions of transcription indicated by arrows. Vertical lines indicate the positions of individual exons.